At Three Forks, the Breakers limited four-time defending State B champ Fairfield to 25 first-half points, but couldn't keep up the pace.
Fairfield (1-0) outscored Loyola 42-18 in the second half on the way to its 105th consecutive win.
Kelsey's Twite's 17 points led the Breakers (0-1) and Makaya Resner added 12. She scored Loyola's only four fourth-quarter points.
Lizzy Klinker and Allie Isakson led Fairfield with 15 points.